On PC: Click on the little uBlock Origin symbol on the url bar, then click on the little gears in the middle right to go to the dashboard, and then select the Filter Lists tab.

To begin, ensure that the first option, auto-updating filter lists, is turned on unless you have a reason for it to be off.

Then, make sure that you have ALL the ad-related filters turned on, and all the annoyances filters selected as well. Only some are selected by default so you need to look them over carefully. Look over the other filters while you’re at it and turn on any others you’ve missed that you think you might want.

Then, once you have enabled all your desired filters, select “Apply changes” and then “Update Now” via the two large buttons at the top left of the page. You should see all the filters go from an orange triangle to something else. Export your new settings if you want a backup of what you just did, and close.

If a filter list you turned on breaks something, just turn the newly enabled ones off again OR whitelist the broken site. But honestly you shouldn’t have any problems, the uBlock Origin filter lists are pretty fine-tuned these days. I have them ALL turned on, lol.

I’ve done this several times over the last few weeks as I’ve been trying out Linux distros and refuse to use Firefox without ad-blocking. Let me know if you have any problems.