Woman complained of forgetfulness and depression before doctors pulled out an 8cm roundworm normally found in pythons

    • @Ranvier@sopuli.xyz
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      71 year ago

      Also based on the picture it was in the right pre frontal cortex. Interesting because most people won’t have much in terms of neurologic symptoms with a lesion here, outside of some subtle mood and executive dysfunction issues maybe. You won’t get like language problems, weakness, numbness, vision loss etc or more obvious symptoms like you would with brain damage other places. Worm found a stealthy spot in the brain to hide in.

      • livusOP
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        51 year ago

        Wonder if they normally hang out in one of the cortex areas of the pythons.

    • @Kalladblog@lemmy.world
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      -11 year ago

      Human induced. Habitat destruction drives more species into more human populated regions

      animals many people wouldn’t get into contact with (be it with animal waste or any other way) happens way more often > chances of diseases formerly only present in certain animals adapting to have human hosts increases

      • livusOP
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        71 year ago

        She was going out and picking native grasses though, pretty sure wilderness areas around Canberra have always had snakes in them.

  • Poggervania
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    551 year ago

    Plot twist: this is an ARG for Larian’s new hit, Baldur’s Gate 3, which include brain worms as part of the main plot

      • Poggervania
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        1 year ago

        For the bit about brain worms being plot important? If so, yep! It’s pretty much the premise of the intro; you’re kidnapped by Lovecraftian-esque beings called “mind flayers” who take you aboard their organic spaceship and have one of their tadpoles wriggle into your brain. Hijinks ensue, and can include tough choices such as “do you resist your violent urges or cut off the funny magic man’s hand?”, “should you condemn a child to death because they committed petty larceny?”, and “do you want to have fuck with the bear?”

  • AutoTL;DRB
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    231 year ago

    This is the best summary I could come up with:


    It was a fairly regular day on the ward for Canberra hospital infectious diseases physician Dr Sanjaya Senanayake, until a neurosurgeon colleague called him and said: “Oh my god, you wouldn’t believe what I just found in this lady’s brain – and it’s alive and wriggling.”

    The neurosurgeon, Dr Hari Priya Bandi, had pulled an 8cm-long parasitic roundworm from her patient, prompting her to call on Senanayake and other hospital colleagues for advice about what to do next.

    The patient, a 64-year-old woman from south-eastern New South Wales, was first admitted to her local hospital in late January 2021 after suffering three weeks of abdominal pain and diarrhoea, followed by a constant dry cough, fever and night sweats.

    The surprising discovery prompted a team at the hospital to quickly come together to uncover what kind of roundworm it was and, most importantly, decide on any further treatment the patient might require.

    Senanayake, who is also an infectious diseases expert based at the Australian National University, said the patient needed to be treated for other larvae that might have invaded other parts of her body, such as the liver.

    The patient is recovering well and is still being regularly monitored, Senanayake said, and researchers are exploring whether a pre-existing medical condition that caused her to be immunocompromised could have led to the larvae taking hold.


    The original article contains 803 words, the summary contains 224 words. Saved 72%. I’m a bot and I’m open source!

  • GreenPlasticSushiGrass
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    201 year ago

    So we got covid, Canada and Hawaii burning, a hurricane in southern California, a right wing insurrection in the US, and microplastics in everything. What’s next? Brainworms, of course!

  • pizza-bagel
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    1 year ago

    I wish this article talked about how they are treating it? They just said she is doing well

    • livusOP
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      1 year ago

      With the actual worm they pulled it out and presumably cleaned up the bit of her brain where it resided.

      For the rest I guess they made her take something that kills nematode parasites, and some strong anti inflammatories?

      said the patient needed to be treated for other larvae that might have invaded other parts of her body, such as the liver. But given no patient had ever been treated for the parasite before, care was taken. Some medications for example could trigger inflammation as the larvae died off. Inflammation can be harmful to organs such as the brain, so they also needed to administer medications to counteract any dangerous side-effects.

      • pizza-bagel
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        71 year ago

        Yeah I just wish they had gone into detail since this was a groundbreaking medical discovery

        • livusOP
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          311 year ago

          I got you fam. From the case write up:

          In June 2022, she underwent an open biopsy. We noted a stringlike structure within the lesion, which we removed; it was a live and motile helminth (80 mm long, 1 mm diameter) (Figure 2, panels B, C). We performed a circumferential durotomy and corticotomy and found no other helminths. Histopathology of the dural tissue revealed a benign, organizing inflammatory cavity with prominent eosinophilia.

          We provisionally identified the helminth as a third-stage larva of Ophidascaris robertsi on the basis of its distinctive red color, 3 active ascaridoid-like lips, presence of a cecum, and absence of a fully developed reproductive system, in the context of the known epidemiologic distribution of this species. The head and tail were preserved at the Australian National Wildlife Collection (W/LHC no. N5758). Small segments underwent independent PCR-based sequencing targeting the cytochrome oxidase c subunit 1 (cox1) (5,6) at the University of Sydney and the second internal transcribed spacer (ITS) 2 of nuclear ribosomal DNA (7) at the University of Melbourne. Both sequencing results provided >99.7% sequence match to Ophidascaris (formerly Amplicecum) robertsi isolates in the National Center for Biotechnology Information and in-house databases (Appendix).

          A progress CT scan revealed resolution of pulmonary and hepatic lesions but unchanged splenic lesions. The patient received 2 days of ivermectin (200 µg/kg/d) and 4 weeks of albendazole (400 mg 2×/d). She was given a weaning course of dexamethasone (starting 4 mg 2×/d) over 10 weeks, while all other immunosuppression was discontinued. Six months after surgery (3 months after ceasing dexamethasone), the patient’s PBEC remained normal. Neuropsychiatric symptoms had improved but persisted.

          And this bit from the conclusion:

          After we removed the larva from her brain, the patient received anthelmintics and dexamethasone to address potential larvae in other organs. Ophidascaris larvae are known to survive for long periods in animal hosts; for example, laboratory rats have remained infected with third-stage larvae for >4 years (4). The rationale for ivermectin and albendazole was based on data from the treatment of nematode infections in snakes and humans (8,9). Albendazole has better penetration into the CNS than ivermectin (10). Dexamethasone has been used in other human nematode and tapeworm infections to avoid deleterious inflammatory CNS responses following treatment (11).

          • Em Adespoton
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            71 year ago

            It’s always dexamethasone.

            I sure hope we don’t get a bunch of stuff developing immunity to that.

      • Probably something like this. There is an entire class of drug rarely needed that does exactly this thing, but won’t kill a fully formed spawn of an egg that wandered into the bloodstream. Antiparasitic drugs are rough, but save thousands of lives per years where this type of parasite is an issue. This case is exactly why doctors may ask if you’ve traveled recently, and to where.

        • @Cypher@lemmy.world
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          31 year ago

          You’re probably speaking about roundworms more generally but this particular parasite has never been observed in humans before.

  • finally debunked
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    1 year ago

    Depression is caused by worms not by chemical imbalance I been constantly told, unbelievable

  • @sndmn@lemmy.ca
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    71 year ago

    I always thought it was mainly hyperbole about everything in Australia tries to kill you.

  • Duży Szef [he/him]
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    71 year ago

    Once in a career finding

    JESUS FUCKING CHRIST I HATE CAPITALISM AND CORPO SPEAK FOR FUCKS SAKE CAN WE TALK ABOUT HUMAN BEINGS OUTSIDE OF THE WORK THEY DO FOR A LIVING FOR FUCKS SAKE AAAAAAAAAAAAAAA

    • Prethoryn Overmind
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      1 year ago

      Oh my god, even you are missing the fucking point if you are distracted by this. Aaaaaa

      Can we stop making our reactions about this kind of thing about the big “corporate” we are telling others to stop making it about?

      I mean come on guys a fucking worm was eating a woman’s brain and you are pissed someone said, “this is probably only something I will find once in my career.” As if a researcher themselves can’t be intrigued, excited, and any other human emotion about their fucking work?

    • @yogo@lemm.ee
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      61 year ago

      I would hope professions, especially doctors, will still exist in a post-capitalist society

      • Duży Szef [he/him]
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        01 year ago

        How about doctors who are approached like people who save lives and help people instead of them being treated as people who do it purely for money?